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    Slc26a7 solute carrier family 26 member 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297910, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Slc26a7provided by RGD
    Official Full Name
    solute carrier family 26 member 7provided by RGD
    Primary source
    RGD:1310846
    See related
    Ensembl:ENSRNOG00000006096 AllianceGenome:RGD:1310846
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable anion transmembrane transporter activity. Predicted to be involved in anion transport and gastric acid secretion. Predicted to act upstream of or within chloride transport. Located in basolateral plasma membrane. Orthologous to human SLC26A7 (solute carrier family 26 member 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 21.4), Kidney (RPKM 15.0) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    5q13
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (32681653..32819110, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (27884400..28021865, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (27986656..28131294, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene DnaJ heat shock protein family (Hsp40) member A1, pseudogene 2 Neighboring gene leucine rich repeat containing 69 Neighboring gene OTU deubiquitinase 6B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Thyroglobulin regulates the expression and localization of the novel iodide transporter solute carrier family 26 member 7 (SLC26A7) in thyrocytes. Kiriya M, et al. Endocr J, 2022 Oct 28. PMID 35644541
    2. SLC26A7 can function as a chloride-loading mechanism in parietal cells. Kosiek O, et al. Pflugers Arch, 2007 Sep. PMID 17404755
    3. Chloride/bicarbonate exchanger SLC26A7 is localized in endosomes in medullary collecting duct cells and is targeted to the basolateral membrane in hypertonicity and potassium depletion. Xu J, et al. J Am Soc Nephrol, 2006 Apr. PMID 16524946
    4. SLC26A7 is a Cl- channel regulated by intracellular pH. Kim KH, et al. J Biol Chem, 2005 Feb 25. PMID 15591059
    5. Increased acid load and deletion of AE1 increase Slc26a7 expression. Sun X, et al. Nephron Physiol, 2008. PMID 18663336

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Thyroglobulin regulates the expression and localization of the novel iodide transporter solute carrier family 26 member 7 (SLC26A7) in thyrocytes.
      Title: Thyroglobulin regulates the expression and localization of the novel iodide transporter solute carrier family 26 member 7 (SLC26A7) in thyrocytes.
    2. Slc26a1, Slc26a6 and Slc26a7 are novel participants in the extracellular transport of bicarbonate during enamel maturation.
      Title: SLC26A Gene Family Participate in pH Regulation during Enamel Maturation.
    3. Suggest that the increase in Slc26a7 expression caused by acid challenge represents an adaptive response, indicating that Slc26a7 contributes to the regulation of acid-base balance by the kidney.
      Title: Increased acid load and deletion of AE1 increase Slc26a7 expression.
    4. SLC26A7 is a Cl(-) uptake system under histamine stimulation
      Title: SLC26A7 can function as a chloride-loading mechanism in parietal cells.
    5. vasopressin increases the expression of SLC26A7 protein through posttranscriptional mechanisms in the outer medullary collecting duct
      Title: Vasopressin induces expression of the Cl-/HCO3- exchanger SLC26A7 in kidney medullary collecting ducts of Brattleboro rats.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables bicarbonate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables bicarbonate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chloride channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chloride transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chloride:bicarbonate antiporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables monoatomic anion channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxalate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxalate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sulfate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sulfate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in bicarbonate transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chloride transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chloride transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chloride transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in gastric acid secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in gluconate transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in iodide transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within monoatomic anion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nitrate transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in oxalate transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sulfate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sulfate transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in thyroid hormone generation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    anion exchange transporter
    Names
    solute carrier family 26 (anion exchanger), member 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106638.1 → NP_001100108.1  anion exchange transporter

      See identical proteins and their annotated locations for NP_001100108.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473962
      UniProtKB/TrEMBL
      A6II93, D3Z8P6
      Related
      ENSRNOP00000058989.1, ENSRNOT00000067331.4
      Conserved Domains (2) summary
      cd07042
      Location:441 → 577
      STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
      TIGR00815
      Location:33 → 582
      sulP; high affinity sulphate transporter 1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      32681653..32819110 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008763531.4 → XP_008761753.1  anion exchange transporter isoform X4

      See identical proteins and their annotated locations for XP_008761753.1

      UniProtKB/TrEMBL
      A6II93, D3Z8P6
      Conserved Domains (2) summary
      cd07042
      Location:441 → 577
      STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
      TIGR00815
      Location:33 → 582
      sulP; high affinity sulphate transporter 1

    2. XM_063287292.1 → XP_063143362.1  anion exchange transporter isoform X3

    3. XM_063287291.1 → XP_063143361.1  anion exchange transporter isoform X2

      UniProtKB/TrEMBL
      A0A1W2Q625

    4. XM_006237911.5 → XP_006237973.1  anion exchange transporter isoform X2

      See identical proteins and their annotated locations for XP_006237973.1

      UniProtKB/TrEMBL
      A0A1W2Q625
      Related
      ENSRNOP00000076107.2
      Conserved Domains (2) summary
      cd07042
      Location:496 → 632
      STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
      TIGR00815
      Location:33 → 637
      sulP; high affinity sulphate transporter 1

    5. XM_039109419.2 → XP_038965347.1  anion exchange transporter isoform X1

      UniProtKB/TrEMBL
      A0A1W2Q610
      Related
      ENSRNOP00000076092.2
      Conserved Domains (1) summary
      TIGR00815
      Location:33 → 673
      sulP; high affinity sulphate transporter 1

    6. XM_039109418.2 → XP_038965346.1  anion exchange transporter isoform X1

      UniProtKB/TrEMBL
      A0A1W2Q610
      Conserved Domains (1) summary
      TIGR00815
      Location:33 → 673
      sulP; high affinity sulphate transporter 1

    7. XM_063287290.1 → XP_063143360.1  anion exchange transporter isoform X2

      UniProtKB/TrEMBL
      A0A1W2Q625

    8. XM_063287289.1 → XP_063143359.1  anion exchange transporter isoform X1

      UniProtKB/TrEMBL
      A0A1W2Q610

    9. XM_039109421.2 → XP_038965349.1  anion exchange transporter isoform X5

      Conserved Domains (2) summary
      cd07042
      Location:439 → 574
      STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
      pfam00916
      Location:3 → 350
      Sulfate_transp; Sulfate permease family

    10. XM_039109422.2 → XP_038965350.1  anion exchange transporter isoform X6

      Conserved Domains (2) summary
      cd07042
      Location:372 → 507
      STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
      pfam00916
      Location:1 → 283
      Sulfate_transp; Sulfate permease family
    Nucleotide Protein Strain
    Heading Accession and Version

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